Evaluation of non-inferiority of intradermal versus adjuvanted seasonal influenza vaccine using two serological techniques: a randomised comparative study.
Identifieur interne : 000E85 ( Main/Exploration ); précédent : 000E84; suivant : 000E86Evaluation of non-inferiority of intradermal versus adjuvanted seasonal influenza vaccine using two serological techniques: a randomised comparative study.
Auteurs : Pierre Van Damme [Belgique] ; Robert Arnou ; Froukje Kafeja ; Anne Fiquet ; Patrick Richard ; Stéphane Thomas ; Gilles Meghlaoui ; Sandrine Isabelle Samson ; Emilio LedesmaSource :
- BMC infectious diseases [ 1471-2334 ] ; 2010.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (administration et posologie), Anticorps antiviraux (sang), Expérimentation humaine, Femelle, Grippe humaine (), Grippe humaine (immunologie), Humains, Immunodiffusion, Injections intradermiques, Injections musculaires, Mâle, Polysorbates (administration et posologie), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (immunologie), Squalène (administration et posologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Tests d'inhibition de l'hémagglutination, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (effets indésirables), Vaccins antigrippaux (immunologie), Vaccins sous-unitaires (administration et posologie), Vaccins sous-unitaires (effets indésirables), Vaccins sous-unitaires (immunologie), Virus influenza B (immunologie).
- MESH :
- administration et posologie : Adjuvants immunologiques, Polysorbates, Squalène, Vaccins antigrippaux, Vaccins sous-unitaires.
- effets indésirables : Vaccins antigrippaux, Vaccins sous-unitaires.
- immunologie : Grippe humaine, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux, Vaccins sous-unitaires, Virus influenza B.
- sang : Anticorps antiviraux.
- Expérimentation humaine, Femelle, Grippe humaine, Humains, Immunodiffusion, Injections intradermiques, Injections musculaires, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests d'inhibition de l'hémagglutination.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (administration & dosage), Aged, Aged, 80 and over, Antibodies, Viral (blood), Female, Hemagglutination Inhibition Tests, Human Experimentation, Humans, Immunodiffusion, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H2N2 Subtype (immunology), Influenza B virus (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (adverse effects), Influenza Vaccines (immunology), Influenza, Human (immunology), Influenza, Human (prevention & control), Injections, Intradermal, Injections, Intramuscular, Male, Polysorbates (administration & dosage), Squalene (administration & dosage), Vaccines, Subunit (administration & dosage), Vaccines, Subunit (adverse effects), Vaccines, Subunit (immunology).
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic, Influenza Vaccines, Polysorbates, Squalene, Vaccines, Subunit.
- chemical , adverse effects : Influenza Vaccines, Vaccines, Subunit.
- chemical , blood : Antibodies, Viral.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza B virus, Influenza Vaccines, Influenza, Human, Vaccines, Subunit.
- prevention & control : Influenza, Human.
- Aged, Aged, 80 and over, Female, Hemagglutination Inhibition Tests, Human Experimentation, Humans, Immunodiffusion, Injections, Intradermal, Injections, Intramuscular, Male.
Abstract
Although seasonal influenza vaccine is effective in the elderly, immune responses to vaccination are lower in the elderly than in younger adults. Strategies to optimise responses to vaccination in the elderly include using an adjuvanted vaccine or using an intradermal vaccination route. The immunogenicity of an intradermal seasonal influenza vaccine was compared with that of an adjuvanted vaccine in the elderly.
DOI: 10.1186/1471-2334-10-134
PubMed: 20504306
Affiliations:
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Le document en format XML
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(immunology)</term><term>Influenza, Human (prevention & control)</term><term>Injections, Intradermal</term><term>Injections, Intramuscular</term><term>Male</term><term>Polysorbates (administration & dosage)</term><term>Squalene (administration & dosage)</term><term>Vaccines, Subunit (administration & dosage)</term><term>Vaccines, Subunit (adverse effects)</term><term>Vaccines, Subunit (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adjuvants immunologiques (administration et posologie)</term><term>Anticorps antiviraux (sang)</term><term>Expérimentation humaine</term><term>Femelle</term><term>Grippe humaine ()</term><term>Grippe humaine (immunologie)</term><term>Humains</term><term>Immunodiffusion</term><term>Injections intradermiques</term><term>Injections musculaires</term><term>Mâle</term><term>Polysorbates (administration et posologie)</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H2N2 du virus de la grippe A (immunologie)</term><term>Squalène (administration et posologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests d'inhibition de l'hémagglutination</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (effets indésirables)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins sous-unitaires (administration et posologie)</term><term>Vaccins sous-unitaires (effets indésirables)</term><term>Vaccins sous-unitaires (immunologie)</term><term>Virus influenza B (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adjuvants, Immunologic</term><term>Influenza Vaccines</term><term>Polysorbates</term><term>Squalene</term><term>Vaccines, Subunit</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Subunit</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Polysorbates</term><term>Squalène</term><term>Vaccins antigrippaux</term><term>Vaccins sous-unitaires</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins sous-unitaires</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Vaccins sous-unitaires</term><term>Virus influenza B</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza B virus</term><term>Influenza Vaccines</term><term>Influenza, Human</term><term>Vaccines, Subunit</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Hemagglutination Inhibition Tests</term><term>Human Experimentation</term><term>Humans</term><term>Immunodiffusion</term><term>Injections, Intradermal</term><term>Injections, Intramuscular</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Expérimentation humaine</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Immunodiffusion</term><term>Injections intradermiques</term><term>Injections musculaires</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests d'inhibition de l'hémagglutination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although seasonal influenza vaccine is effective in the elderly, immune responses to vaccination are lower in the elderly than in younger adults. Strategies to optimise responses to vaccination in the elderly include using an adjuvanted vaccine or using an intradermal vaccination route. The immunogenicity of an intradermal seasonal influenza vaccine was compared with that of an adjuvanted vaccine in the elderly.</div></front></TEI><affiliations><list><country><li>Belgique</li></country><region><li>Province d'Anvers</li><li>Région flamande</li></region><settlement><li>Anvers</li></settlement><orgName><li>Université d'Anvers</li></orgName></list><tree><noCountry><name sortKey="Arnou, Robert" sort="Arnou, Robert" uniqKey="Arnou R" first="Robert" last="Arnou">Robert Arnou</name><name sortKey="Fiquet, Anne" sort="Fiquet, Anne" uniqKey="Fiquet A" first="Anne" last="Fiquet">Anne Fiquet</name><name sortKey="Kafeja, Froukje" sort="Kafeja, Froukje" uniqKey="Kafeja F" first="Froukje" last="Kafeja">Froukje Kafeja</name><name sortKey="Ledesma, Emilio" sort="Ledesma, Emilio" uniqKey="Ledesma E" first="Emilio" last="Ledesma">Emilio Ledesma</name><name sortKey="Meghlaoui, Gilles" sort="Meghlaoui, Gilles" uniqKey="Meghlaoui G" first="Gilles" last="Meghlaoui">Gilles Meghlaoui</name><name sortKey="Richard, Patrick" sort="Richard, Patrick" uniqKey="Richard P" first="Patrick" last="Richard">Patrick Richard</name><name sortKey="Samson, Sandrine Isabelle" sort="Samson, Sandrine Isabelle" uniqKey="Samson S" first="Sandrine Isabelle" last="Samson">Sandrine Isabelle Samson</name><name sortKey="Thomas, Stephane" sort="Thomas, Stephane" uniqKey="Thomas S" first="Stéphane" last="Thomas">Stéphane Thomas</name></noCountry><country name="Belgique"><region name="Région flamande"><name sortKey="Van Damme, Pierre" sort="Van Damme, Pierre" uniqKey="Van Damme P" first="Pierre" last="Van Damme">Pierre Van Damme</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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